VAGINAL DELIVERY
The vaginal route of administration offers a promising option for local and systemic delivery of drugs.
Suppositories,
creams, gels and tablets are commonly used vaginal drug delivery
systems. These conventional vaginal formulations, however, are
associated with limitations of poor retention, leakage, and messiness,
thereby causing inconvenience to users.
To overcome these limitations,
formulations that adhere to the vaginal mucosa for a sufficient period
of time need to be developed. Bioadhesion and retention are desirable
characteristics of a vaginal formulation to achieve desired efficacy.
These properties can be built in during formulation development by the
use of bioadhesive polymers and tested by similar methods to those
already discussed for bioadhesion. The limitations have also
necessitated the development of other novel drug delivery systems.
OCULAR DELIVERY
Treatment
of some diseases is best achieved by direct administration near the
affected area, particularly with diseases involving ophthalmic, optic,
dermal, oral cavity, and anorectal tissues.
Ocular drug
delivery is an interesting and challenging opportunity for
pharmaceutical development. The eye is protected by a series of complex
defense mechanisms, which usually result in poor bioavailability of
drugs administered via the ocular route. These include tear production
and the blinking reflex in addition to short residence time and reduced
drug permeability.
PARENTERAL DELIVERY
Developments in injectable depots and implants are driven by a desire to decrease the necessity for frequent medication.
Incorporating
polymer technology for slow, long-term release, this route is best
utilised for the treatment of chronic conditions, such as heart disease
and pain management. Hip or knee cap replacements are susceptible to
infection following surgery.
A preventative approach could be
for the doctor to leave behind an implant that could deliver an
anti-infective agent and disintegrate with time. These devices give
localised, high-concentration delivery, and by tuning the ratio of drug
load to polymer the required release rate can be optimised, over two
days or two months.
PULMONARY DELIVERY
Pulmonary delivery has been used for years to treat respiratory diseases by delivering drugs locally to the lung.
However, the latest advances are seeing drugs being delivered via this route for systemic circulation. The delivery of drugs to the bloodstream via the lungs is an attractive hypothesis, offering a non-invasive and rapid-onset alternative to injections.
Inhalation Drug Delivery via Metered-dose Inhalers
Aerosol route of administration targets drugs directly to the lungs and offers advantages of bypassing the first pass elimination, reducing the dosage frequency and minimising the extent of adverse drug reactions.
INTRODUCTION
The latest craze to sweep the pharmaceutical industry is one of controlled-release drug delivery systems.
This
controlled release can be systemic (generally via the bloodstream), as
is generally the case for oral preparations, or act specifically at the
site of greatest benefit (for example, in implanted devices) and these
dosage forms are defined as preparations that modify the rate and/or the
time and/or site of release of the active ingredient, in order to
achieve specific therapeutic objectives which cannot be achieved with
conventional dosage forms similarly administered.
Whether you are new to texture analysis, are an experienced super user, or have specific requirements, you now have the flexibility to choose how you interact with a Connect Texture Analyser.
We offer three ways to run your instrument. Each can be used independently from each other, or you can have a combination of all three. Whichever suits your requirements, the choice is yours.
How to operate your Texture Analyser
Touchscreen
The Touchscreen is supplied with all of our Connect Texture Analysers and is capable of controlling your instrument and running simple tests. It is ideal for providing a quick result with some single point analysis, such as Maximum Forces in both compression and tension tests.
The UNIVERSAL PEEL RIG (A/UPS) is a flexible solution to peel testing.
Significant improvements have been made to previous designs of peel rig for evaluating the quality and strength of container seals and adhesive bonds.
The Universal Peel Rig consists of a multi-position platform which is adjustable to allow the container to be held at 0, 45 and 90 degrees; the platform is screwed securely into position on the base of the Texture Analyser to suit the container.
PERSONAL CARE PRODUCT PACKAGING
Not
only are the texture and physical appearance of personal care products
crucial for achieving aesthetic appeal and optimal functionality, but
other factors concerning their look and feel can dictate their
popularity.
The packaging of a product can have a profound
influence over purchasing decisions. Catchy names and bright colours are
part of the attraction but packaging that performs the essential
preservation function and is easy to use is also a key persuasion.
Regardless
of product density, several texture analysis examinations can aid
manufacturers in producing the best packaging to suit the personal care
product in question. With tubs, tubes, sachets and various other vessels
being available, it is essential that the correct packaging format is
chosen in order for consumers to make complete and convenient use of
their personal care products.
